Columbus, Cincinnati, and Cleveland are all emerging as vibrant hubs of innovation and entrepreneurship, making Ohio home to many rising tech companies. Columbus has been a standout performer, with a 2023 report from the Columbus Partnership highlighting a 22% growth in tech jobs over the past five years. The city's focus on sectors such as fintech, health tech, and logistics has attracted both startups and established companies, making it a magnet for tech talent.
Cincinnati and Cleveland are also making significant strides, supported by robust initiatives aimed at fostering collaboration and investment. Cincinnati's tech scene saw venture capital investments exceeding $300 million in 2022, driven by a growing number of startups in areas like healthcare and e-commerce. Meanwhile, Cleveland's commitment to innovation is evident in its expanding network of incubators and accelerators, which are helping to launch new ventures.
Collectively, these cities are reshaping Ohio’s reputation in the tech landscape, positioning the state as a competitive player in the national arena. Here are 20 tech companies in Ohio to keep on your radar in 2025.
Top Tech Companies In Cincinnati, Ohio
Image source: Abre website
Abre
Abre, an education technology company based in Cincinnati, has made significant strides in the tech industry. The company successfully raised $24 million in Series A funding earlier this spring to help K-12 schools centralize and make sense of siloed data.
CinRX Pharma
CinRX Pharma is a pharmaceutical company that invests in and expertly guides drug candidates through development with a focus on therapies with the potential to transform treatment. The company raised an impressive $73 million in Series B funding, highlighting the potential of their drug development pipeline. Additionally, CinDome Pharma, one of CinRX's portfolio companies, announced a $40 million Series B extension in May 2024, further solidifying the group's position in the pharmaceutical industry.
Image source: Cloverleaf website
Cloverleaf
Cloverleaf is a talent development platform. The company’s technology turns assessment results into continuous, personalized learning with Automated Coaching. In March 2024, the company raised $7.3 million in a Series A extension funding round. This new influx of capital is expected to help Cloverleaf expand its operations and enhance its product offerings.
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Image courtesy of Gearsupply
Gearsupply
One of the top emerging tech companies in Ohio, Gearsupply is an online marketplace for buying and selling used AV equipment. It’s all a part of the company’s mission to reduce the amount of gear going to the landfill. Last year the company moved its headquarters to Findlay Market in OTR and is continuing to grow.
Scheduler AI
Scheduler AI, an artificial intelligence startup based in Cincinnati, has recently made waves in the tech investment scene. The company successfully raised $2.8 million in a Seed Round led by Drive Capital in June 2024. This funding will help accelerate Scheduler AI's development of innovative AI-powered scheduling solutions.
Tembo
Tembo provides a Postgres managed service for organizations to handle open-source databases for transactional, analytical and AI workloads. In July this year, the company raised $14 million in a Series A funding round. This investment is expected to help Tembo expand its operations and further develop its product offerings.
Top Tech Companies In Cleveland, Ohio
Cell X Technologies
Cell X Technologies, a Cleveland-based biotech company, is leveraging robotics, imaging, and artificial intelligence to revolutionize cell processing. In August 2024, the company raised $6 million to support its innovative work in cell technologies. This funding will accelerate Cell X Technologies' research and development efforts in the biotechnology sector, making it a top tech company to watch in Ohio.
Champ
Top Cleveland tech company Champ builds technology for governments that solve title and registration issues for vehicle retailers, vehicle wholesalers, insurance carriers, and more. The company raised $18 million earlier this spring to fuel its growth.
Image source: Cleveland Diagnostics X
Cleveland Diagnostics
Cleveland Diagnostics offers novel, more accurate testing for early detection of cancer and risk of high-grade disease. This top biotech company in Ohio raised $75 million, showcasing the potential of their diagnostic technologies. This substantial investment will help accelerate Cleveland Diagnostics' research and development efforts and market expansion.
NeuroTherapia
NeuroTherapia is another top Cleveland biotech company that has recently completed a successful funding round. In August 2024, the company raised $12.3 million in a Series B funding round led by Cleveland Clinic. This funding will primarily be used for the continued clinical development of NTRX-07, an orally available cannabinoid receptor agonist, for the treatment of Alzheimer's disease.
OnStation
OnStation is a collaborative digital stationing platform that provides location-based project record from bid to close for roadway projects. Earlier this summer, OnStation raised $8.5 million in Series A funding to help expand its operations and further develop its technology platform.
Image source: SPR Therapeutics website
SPR Therapeutics
SPR Therapeutics is a medical device company that helps relieve chronic and acute pain. The company raised $25 million in Series D funding back in February, bringing its total funding up to over $188 million.
Top Tech Companies in Columbus, Ohio
Image source: AssetWatch website
AssetWatch
One of the top emerging tech companies in Columbus, Ohio, AssetWatch is a predictive maintenance solution provider. The company raised $38 million in Series B funding in May 2024. This substantial investment is expected to accelerate AssetWatch's growth and enhance its predictive maintenance technologies.
Clarametyx Biosciences
Clarametyx Biosciences is an innovative biotech company working beyond antibiotics to fight life-threatening bacterial infections. The company raised $33 million in Series A funding in January 2024.
Finite State
Finite State is a cybersecurity startup helping manage risk across the software supply chain. The company raised $20 million in Series B funding in March, demonstrating strong investor confidence in their cybersecurity solutions. Later in June, Finite State further expanded its capabilities by acquiring MergeBase, solidifying its position in the cybersecurity market.
HubiFi
HubiFi is an emerging tech company in Columbus, Ohio, automating revenue recognition and reporting. In August 2024, the company raised $2.5 million in a seed round to automate revenue management for high-transaction enterprises. This funding is expected to help HubiFi further develop its technology and expand its market reach.
Power to Hydrogen
Power to Hydrogen is a clean energy startup leading the way in advanced electrolysis technologies for the production of green hydrogen. The company raised $18 million in a Series A funding round to accelerate the transition to clean energy. The round was led by Rev1 Ventures and Worthington Enterprises.
Image source: RediHealth
Redi Health
Redi Health is a rising health tech company in Columbus. It combines health management technology and integrated patient support to empower patients. The company raised $14 million in Series B funding in March 2024 to fuel its growth.
Image courtesy of RWX
RWX
Founded by Root alumni, RWX is building a CI/CD platform that provides unmatched capabilities and the best developer experience in CI/CD. Earlier this year, the company raised $7 million in a seed round and subsequently launched Mint, a Continuous Integration and Continuous Deployment (CI/CD) platform. This funding and product launch position RWX as a promising player in the software development tools market.
Trace
Founded by three former employees of Magic Leap, Trace is an augmented reality (AR) startup. After its $2 million fundraise, the founders established its headquarters in Ohio. Led by "boomerang" founder Greg Tran, who returned to Columbus after spending time in Miami and San Francisco, Trace represents a growing trend of tech talent returning to the Midwest.
Niobium
Based in Dayton, Ohio, Niobium is a custom silicon provider that has recently secured seed funding to support its innovative work. The company raised a $5.5 million seed round to revolutionize the field of Zero Trust Computing with its cryptography hardware. This funding is expected to accelerate Niobium's development of cutting-edge silicon solutions for secure computing.
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